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Advanced Testing

DNA₁ Advanced Alpha-1 Screening™: Find the 1-in-20 Alphas that other tests may miss¹⁵

The DNA₁ Advanced Alpha-1 Screening Test Kit is the only test for Alpha-1 that provides comprehensive next-generation screening for an accurate and confident diagnosis without the need for additional testing.

Advanced testing – Next-generation sequencing

Advanced testing – Isoelectric focusing (IEF)

Learn more about the DNA₁ Advanced Alpha-1 Screening Test Kit by selecting each group.

Targeted genotyping

DNA₁ looks beyond the most common alleles to identify cases involving NULL or rare variants that might otherwise be missed

Next-generation sequencing of the SERPINA1 gene

There are over 120 known variants to the SERPINA1 gene¹⁶
Sequencing of all exons, splice sites, and the promoter region of the SERPINA1 gene help you identify all Alpha-1 patients and carriers
DNA₁ provides full next-generation genetic sequencing of the SERPINA1 gene to identify known and previously undiscovered variants

Clinical chemistry

DNA₁ is the only available test that screens for both A₁AT protein levels and C-reactive protein (CRP) levels to give context to the A₁AT results and help prevent false negatives*

*CRP, like A₁AT, is an acute-phase protein, which means levels of it may be elevated with inflammation. This CRP test is not a high-sensitivity test; it is used as a measurement of inflammation.

Isoelectric focusing (IEF)

IEF phenotyping results serve as a confirmatory step for genotyping results, giving added confidence that results are accurate. With DNA₁, there is typically no need to retest

Accurate and Convenient Testing and Results

The DNA₁ Advanced Alpha-1 Screening Test Kit offers both accuracy and convenience when detecting Alpha-1, and there is no charge for the kit, lab processing, or lab results.

The AdvanceDx100 serum separator card simplifies test administration:

Only 1 blood spot (an average of 4 to 6 drops of blood) needed
30-minute drying time
Accurate and confident diagnosis without the need for additional testing

Administering the DNA₁ Advanced Alpha-1 Screening Test

Watch a video of the blood collection process for the DNA₁ Advanced Alpha-1 Screening test

Support and Guidance for Abnormal Test Results

Upon delivery of an abnormal test result, you will be provided with a copy of the patient’s results plus additional information and guidance to assist with helping your patients take the next step from diagnosis to appropriate therapy, including:

A physician's guide to assist you with interpreting your patient's test results, including talking points for patient education
A patient education brochure providing information about Alpha-1 diagnosis and what to expect next

Genetic Counseling

Patients and family members are encouraged to call the Alpha-1 Genetic Counseling Center to learn more.

Call 1-800-785-3177.

Is there an undiscovered Alpha in your practice? Discover DNA₁ Advanced Alpha-1 Screening:

The only DNA₁ test with next-generation sequencing that provides accurate results without the need to retest.

Order your FREE test kit today

Get an in-depth look at the science behind the DNA₁ test

Chris Sanders, Founder and CEO of Biocerna, the company that developed DNA₁ for CSL Behring, discusses the rationale for creating the test and explains its unique, 4-faceted test methodology.

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