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Advanced Testing
DNA1 Advanced Alpha-1 Screening™: Find the 1-in-20 Alphas that other tests may miss15
The DNA1 Advanced Alpha-1 Screening Test Kit is the only test for Alpha-1 that provides comprehensive next-generation screening for an accurate and confident diagnosis without the need for additional testing.
Learn more about the DNA1 Advanced Alpha-1 Screening Test Kit by selecting each group.
Targeted genotyping
- DNA1 looks beyond the most common alleles to identify cases involving NULL or rare variants that might otherwise be missed
Next-generation sequencing of the SERPINA1 gene
- There are over 120 known variants to the SERPINA1 gene16
- Sequencing of all exons, splice sites, and the promoter region of the SERPINA1 gene help you identify all Alpha-1 patients and carriers
- DNA1 provides full next-generation genetic sequencing of the SERPINA1 gene to identify known and previously undiscovered variants
Clinical chemistry
- DNA1 is the only available test that screens for both A1AT protein levels and C-reactive protein (CRP) levels to give context to the A1AT results and help prevent false negatives*
*CRP, like A1AT, is an acute-phase protein, which means levels of it may be elevated with inflammation. This CRP test is not a high-sensitivity test; it is used as a measurement of inflammation.
Isoelectric focusing (IEF)
- IEF phenotyping results serve as a confirmatory step for genotyping results, giving added confidence that results are accurate. With DNA1, there is typically no need to retest
Accurate and Convenient Testing and Results
The DNA1 Advanced Alpha-1 Screening Test Kit offers both accuracy and convenience when detecting Alpha-1, and there is no charge for the kit, lab processing, or lab results.
The AdvanceDx100 serum separator card simplifies test administration:
- Only 1 blood spot (an average of 4 to 6 drops of blood) needed
- 30-minute drying time
- Accurate and confident diagnosis without the need for additional testing
Administering the DNA1 Advanced Alpha-1 Screening Test
Watch a video of the blood collection process for the DNA1 Advanced Alpha-1 Screening test
Support and Guidance for Abnormal Test Results
Upon delivery of an abnormal test result, you will be provided with a copy of the patient’s results plus additional information and guidance to assist with helping your patients take the next step from diagnosis to appropriate therapy, including:
- A physician's guide to assist you with interpreting your patient's test results, including talking points for patient education
- A patient education brochure providing information about Alpha-1 diagnosis and what to expect next
Patients and family members are encouraged to call the Alpha-1 Genetic Counseling Center to learn more.
Call 1-800-785-3177.
Get an in-depth look at the science behind the DNA1 test
Chris Sanders, Founder and CEO of Biocerna, the company that developed DNA1 for CSL Behring, discusses the rationale for creating the test and explains its unique, 4-faceted test methodology.
