Notice of special administration instructions for Zemaira. Read more here X


A simple blood test makes all the difference.

Alpha-1 testing

  • Alpha-1 antitrypsin deficiency (Alpha-1) is a condition passed from parents to their children through their genes.1
  • Patients at increased risk, including adults with emphysema, should be tested. According to the American Thoracic Society guidelines, you should be screened for Alpha-1 if you have ANY of the following2:
    • COPD, emphysema, or irreversible asthma.
    • Persistent obstruction on pulmonary function tests with known risk factors.
    • A sibling with Alpha-1.
    • Unexplained liver disease.
  • Testing for Alpha-1 is quick, simple, accurate, and free. It only requires a few drops of blood from a finger stick.
  • A retrospective study reported that it took an average of 7.8 years between patients’ initial symptoms and correct diagnosis of Alpha-1. In addition, 43% of patients reported seeing at least 3 physicians before receiving a correct diagnosis.3

To learn more about the importance of testing for Alpha-1, call the Alpha-1 Genetic Counseling Center at

Understanding your test results

  • Upon reviewing your results, your doctor may recommend preventive measures that can help you take better control of your health.
  • If you feel comfortable, encourage your family members to speak with their doctor about being tested.4 The earlier Alpha-1 is identified, the sooner affected family members can take the necessary steps to better manage their health.1
  • An example of how Alpha-1 may be inherited:
  • The following brochure serves as a follow-up to the conversation you had with your doctor. It aims to help you better understand a diagnosis of Alpha-1, your recent Alpha-1 blood test results, and the community of people available to support you.

Alpha-1 antitrypsin deficiency diagnosis

  • If your doctor has given you an Alpha-1 diagnosis, you may be contacted by support services to help you start and stay on augmentation therapy.
  • Zemaira augmentation therapy is a weekly infusion that replaces the protein you are missing and raises alpha-1 antitrypsin levels in the blood.
  • In addition to Zemaira augmentation therapy, some simple lifestyle steps can help give you some breathing room from Alpha-1. View more health tips at alpha-1

Listen to an expert discuss how Alpha-1 may impact your life.

If at any time you have questions regarding Alpha-1, your test results, or your diagnosis, we urge you to talk to your doctor.

Important Safety Information

Alpha1-Proteinase Inhibitor (Human), Zemaira® is indicated to raise the plasma level of alpha1-proteinase inhibitor (A1-PI) in patients with A1-PI deficiency and related emphysema. The effect of this raised level on the frequency of pulmonary exacerbations and the progression of emphysema have not been established in clinical trials.

Zemaira may not be suitable for everyone; for example, people with known hypersensitivity to components used to make Zemaira, those with a history of anaphylaxis or severe systemic response to A1-PI products, and those with certain IgA deficiencies. If you think any of these may apply to you, ask your doctor.

Early signs of hypersensitivity reactions to Zemaira include hives, rash, tightness of the chest, unusual breathing difficulty, wheezing, and feeling faint. Immediately discontinue use and consult with physician if such symptoms occur.

In clinical studies, the following adverse reactions were reported in at least 5% of subjects receiving Zemaira: headache, sinusitis, upper respiratory infection, bronchitis, fatigue, increased cough, fever, injection-site bleeding, nasal symptoms, sore throat, and swelled blood vessels.

Because Zemaira is made from human blood, the risk of transmitting infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent, cannot be completely eliminated.

Please see full prescribing information for Zemaira.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Zemaira is manufactured and distributed by CSL Behring LLC.
Zemaira® and CareZ® are registered trademarks of CSL Behring LLC.

© 2018 CSL Behring LLC. The product information presented on this site is intended for US residents only. ZMR03-13-0022(3) 6/2015