Notice of special administration instructions for Zemaira. Read more here

How can Zemaira work for you?

Zemaira replaces a vital protein that your body is missing

  • Zemaira is augmentation (replacement) therapy for people who have Alpha-1 disease and are unable to produce enough alpha-1 antitrypsin (A1AT) protein
  • Zemaira is a natural Alpha-1 protein that is derived from human plasma. Zemaira replaces the protein that you are missing and raises A1AT protein levels in the blood
  • Zemaira is not a cure for Alpha-1, but it has been proven to raise the levels of A1AT protein, which your body needs to maintain good lung health
  • Zemaira is approved by the FDA for chronic augmentation and maintenance therapy in adults with Alpha-1 and emphysema
  • Clinical data demonstrating the long-term effects of chronic augmentation therapy are not available


Alpha-1 is a journey. Zemaira can be with you every step of the way

Proven Effective

Safe

Convenient Dosing and Administration

Short Infusion Time

Zemaira is proven in clinical trials to raise and maintain serum levels of A1AT protein13

  • A1AT is a protein that is produced in the liver and released into the blood, transporting it to your lungs to protect them against damage14
  • The long-term effects of chronic augmentation therapy with Zemaira are not available

Zemaira is safe, with few and generally mild side effects

  • The following adverse reactions were reported in at least 5% of patients receiving Zemaira in clinical trials: headache, sinusitis, upper respiratory infection, bronchitis, fatigue, increased cough, fever, injection-site bleeding, nasal symptoms, sore throat, and swelled blood vessels
  • Zemaira is purified from human plasma and undergoes a rigorous virus-removal and inactivation process

While all efforts are made to prevent transmission of infectious agents and viruses, the risk of transmission cannot be completely eliminated.

Zemaira is a once-weekly treatment that takes about 15 minutes to infuse

  • The recommended dose of Zemaira is 60 mg/kg body weight, administered once weekly
  • Zemaira is administered by intravenous infusion once a week at an infusion center or in your own home
  • Zemaira can be stored safely at room temperature

Zemaira has a low-volume formulation. For most patients, this allows for Zemaira to be infused in approximately 15 minutes once a week

  • Dosing is weight-based. Individual time of infusion will vary; 15-minute infusion time is based on a patient weighing 165 pounds
  • Rate of administration is also based on the response and comfort of the patient

CSL Behring: A heritage of high-quality plasma manufacturing safety standards that goes back more than 60 years

CSL Behring employs an expert team of virologists and quality-assurance systems and controls to fractionate (purify) human plasma so that it meets the most rigorous and powerful industry standards.

Female Scientist

Zemaira purity

Zemaira is purified from human plasma and undergoes a rigorous virus removal and inactivation process.

  • Zemaira has been used for over 10 years with no confirmed cases of virus transmission15
  • While all efforts are made to prevent the transmission of infectious agents and viruses, the risk of transmission cannot be completely eliminated

Manufacturing standards

Zemaira is made in a state-of-the-art facility under strict, controlled conditions. The process includes 2 virus clearance steps:

  • Heat treatment at 60°C for 10 hours
  • Nanofiltration – a process that can separate and remove particles as small as a virus


Ask your doctor about Alpha-1 and learn more here

With DNA1 Advanced Alpha-1 Screening™, there is typically no need to retest

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